VASCULAR BIOLOGY RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG
نویسندگان
چکیده
1Division of Cardiology, 2Division of Molecular and Vascular Medicine and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; 3Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; 4Department of Medical Pharmacology, School of Medicine and Dalton Cardiovascular Sciences Center, University of Missouri-Columbia, Columbia, MO; 5Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; 6Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; 7Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and 8Department of Physiology and Pathology and Anatomical Sciences, School of Medicine and Dalton Cardiovascular Sciences Center, University of Missouri-Columbia, Columbia, MO
منابع مشابه
RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG.
ERG is a member of the ETS transcription factor family that is highly enriched in endothelial cells (ECs). To further define the role of ERG in regulating EC function, we evaluated the effect of ERG knock-down on EC lumen formation in 3D collagen matrices. Blockade of ERG using siRNA completely interferes with EC lumen formation. Quantitative PCR (QPCR) was used to identify potential downstream...
متن کاملThe role of RhoJ in endothelial cell biology and angiogenesis.
RhoJ is an endothelially expressed member of the Cdc42 (cell division cycle 42) subfamily of small Rho GTPases. It is expressed in both the developing mammalian vasculature and the vascular beds of a number of adult tissues, with its expression regulated by the endothelial transcription factor ERG (ETS-related gene). RhoJ has been shown to regulate endothelial motility, tubulogenesis and lumen ...
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OBJECTIVE RhoJ/TCL was identified by our group as an endothelial-expressed Rho GTPase. The aim of this study was to determine its tissue distribution, subcellular localization, and function in endothelial migration and tube formation. METHODS AND RESULTS Using in situ hybridization, RhoJ was localized to endothelial cells in a set of normal and cancerous tissues and in the vasculature of mous...
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تاریخ انتشار 2011